ROLE OF ALDOSTERONE

For patients with systolic blood pressure >140 mm Hg despite taking 2 or more antihypertensives

Targeting aldosterone at the source may represent a novel therapeutic approach for patients with uncontrolled hypertension^[1],[2]

ALDOSTERONE plays an important role in blood pressure regulation^[3a]

As a central component of the RAAS pathway, aldosterone is responsible for controlling blood pressure by regulating the balance of sodium, potassium, and water in the body.^[3b],[4],[5]

Beyond the RAAS, excess circulating aldosterone contributes to inflammation and fibrosis of the heart, vasculature, and kidneys, leading to end-organ damage.^[6],[7]

There are 18 classes of antihypertensives available, yet many patients are still uncontrolled^[8]

It's time to think about a different approach

ACEis inhibit angiotensin-converting enzyme (ACE) to prevent the conversion of angiotensin I to angiotensin II, reducing vasoconstriction^[9]

ARBs inhibit the binding of angiotensin II to the AT1 receptor, reducing vasoconstriction and sympathetic activity^[10]

CCBs prevent the movement of calcium into the cells of blood vessels, resulting in vasodilation^[11]

Thiazide diuretics inhibit sodium reabsorption in the kidney, promoting natriuresis and diuresis, reducing intravascular volume^[12]

MRAs bind to and block the mineralocorticoid receptor to prevent aldosterone from activating it, decreasing sodium reabsorption and reducing fluid volume^[13]

COULD TARGETING ALDOSTERONE AT THE SOURCE BE A MISSING LINK IN THE TREATMENT OF HARD-TO-CONTROL HYPERTENSION?

This list represents selected antihypertensive medications for educational purposes and does not represent a comprehensive treatment list.

For many people with hypertension, aldosterone dysregulation may be an underlying cause—UNDERRECOGNIZED FOR FAR TOO LONG.^{1,2 14,15 1 2 1 2 5,7}

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For many people with hypertension, aldosterone dysregulation may be an underlying cause—UNDERRECOGNIZED FOR FAR TOO LONG.^{1,2 14,15 7,8 9,10 5,7}

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Targeting aldosterone at the source may represent a novel therapeutic approach for patients with uncontrolled hypertension[1],[2]

ALDOSTERONE plays an important role in blood pressure regulation[3a]